Robert F. Kennedy Jr.’s confirmation as health secretary is riding on the decisions of a small group of Republicans. To secure the position, he can only lose up to three GOP votes if every Democrat stands against him—and it’s still unclear if all Democrats will oppose his nomination.

During his first confirmation hearing on Wednesday, Kennedy’s performance was shaky, but it hasn’t immediately swayed any Republicans to publicly oppose him. Some GOP senators have raised concerns about his stance on abortion and his history of opposing vaccines, but similar reservations didn’t stop Pete Hegseth from being confirmed as defense secretary earlier in the Trump administration.

The key players in this decision are Senators Susan Collins of Maine and Lisa Murkowski of Alaska. Both have a track record of breaking with their party, including voting to convict President Trump during his second impeachment trial and opposing Hegseth’s confirmation. As the only Republican senators who support reproductive rights, their votes could make or break Kennedy’s nomination.

Kennedy’s fate now rests in their hands, along with a few other Republicans who have shown independence in the past. As the confirmation process unfolds, all eyes will be on this small group to see if they’ll back the president’s pick or take a stand against him.